Flow cytometry in transfusion medicine: an overview

ConclusionFlow cytometry has the advantages of a higher sensitivity for some antigens than in traditional serology and the ability to easily distinguish between two or more populations of cells, which makes it a useful tool in many clinical settings, for example in defining chimeras and in detection of fetomaternal bleeding. The combination of molecular testing and the detection of surface antigens by flow cytometry are found useful. When resolving clinically relevant ABO discrepancies we have found the combination of genetic testing and semiquantification of ABO antigens by flow cytometry very helpful. Taken together flow cytometry is a handy tool in clinical routine analysis as well as in research focusing on transfusion medicine.
Source: ISBT Science Series - Category: Hematology Authors: Tags: Congress Review Source Type: research