Catalytic Asymmetric [4 2]-Cycloaddition of Dienes with Aldehydes

JacsCatalytic Asymmetric [4 2]-Cycloaddition of Dienes with Aldehydes: Despite its significant potential, a general catalytic asymmetric [4+2]-cycloaddition of simple and electronically unbiased dienes with any type of aldehyde has long been unknown. Previously developed methodologies invariably require activated, electronically engineered substrates. We now provide a general solution to this problem. We show that highly acidic and confined imidodiphosphorimidates (IDPis) are extremely effective Br ønsted acid catalysts of the hetero-Diels–Alder reaction of a wide variety of aldehydes and dienes to give enantiomerically enriched dihydropyrans.

Source: Organometallic Current - September 27, 2017 Category: Chemistry Tags: Cycloaddition Hetero-Diels-Alders-Reactions Source Type: blogs