A protective role of IRF3 and IRF7 signalling downstream TLRs in the development of vein graft disease via type I interferons

ConclusionsThe present study is the first to describe a protective role of both IRF3 and IRF7 in VGD. IRFs regulate VGD downstream TLRs since Irf3−/− and Irf7−/− vein grafts show increased vessel wall thickening after respectively 14 and 28 days after surgery.

Source: Journal of Internal Medicine - September 27, 2017 Category: Internal Medicine Authors: K. H. Simons, H. A. B. Peters, J. Wouter Jukema, M. R. Vries, P. H. A. Quax Tags: Original Article Source Type: research