Decline in the Acute Insulin Response in Relationship to Plasma Glucose Concentrations
ConclusionsWith worsening insulin action, the decline in insulin secretion occurred prior to current diagnostic guidelines for impaired glucose regulation. However, the relationship between AIR and increasing PG varies, and was not always non‐linear. Understanding the dynamics of this relationship may determine when to initiate preventive pharmacotherapy directed at the preservation of β‐cell failure.
Source: Diabetes/Metabolism Research and Reviews - Category: Endocrinology Authors: Sascha Heinitz, Paolo Piaggi, Clifton Bogardus, Jonathan Krakoff Tags: RESEARCH ARTICLE Source Type: research