Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions

We examined the morphology of the well‐developed Dab1 deficient HF by staining with a silver impregnation method in this report, and found that disruption of lamination in the CA1, CA3, and DG was different. Abnormalities observed in the development of Dab1 deficient CA1 were similar to those reported in the neocortical development, while Dab1 deficient CA3 neuronal progenitors radially spreaded beyond presumptive pyramidal layer. The intermediate progenitor cells ectopically located in the Dab1 deficient DG, but neurogenesis was normal in the CA1 and CA3. These observations suggest that the morphogenesis in these HF subdivisions employs different developmental mechanisms involving Dab1 function.

By detailed observations of developmental process of the hippocampal formation in Dab1 deficient mice, it was found that morphogenesis in the CA1, CA3, and dentate gyrus in the mutant was differently affected by Dab1 deficiency, suggesting that Dab1 is involved in these hipocampla subdivisions collaborating with different developmental mechanisms.

Source: Development, Growth and Differentiation - September 1, 2017 Category: Research Authors: Marissa Blume, Fuduki Inoguchi, Taku Sugiyama, Yuji Owada, Noriko Osumi, Yoshinari Aimi, Kosuke Taki, Yu Katsuyama Tags: Original Article Source Type: research