Reduced collagen accumulation and augmented MMP-2 activity in left ventricle of old rats submitted to high-intensity resistance training

In conclusion, RT attenuated age-associated collagen accumulation, concomitant to the increase in MMP-2 activity and decreased expression of COL-I, TGF-β1, and TIMP-1 in LV, illustrating a cardioprotective effect of RT on ventricular structure and function.
NEW & NOTEWORTHY We demonstrated the beneficial resistance-training effect against age-related left ventricle collagen accumulation in the left ventricle, which was associated with decreased type I collagen (COL-I), transforming growth factor-β1 (TGF-β1), and tissue inhibitor of metalloproteinases-1 (TIMP-1) gene expression and matrix metalloproteinase-2 (MMP-2) activity. Our findings suggest for the first time the potential effects of resistance training in modulating collagen accumulation and possibly fibrosis in the aging heart.

Source: Journal of Applied Physiology - September 25, 2017 Category: Physiology Authors: Guzzoni, V., Marqueti, R. d. C., Durigan, J. L. Q., Faustino de Carvalho, H., Lino, R. L. B., Mekaro, M. S., Costa Santos, T. O., Mecawi, A. S., Rodrigues, J. A., Hord, J. M., Lawler, J. M., Davel, A. P., Selistre-de-Araujo, H. S. Tags: RESEARCH ARTICLE Source Type: research