Sodium nitrate ingestion increases skeletal muscle nitrate content in humans

In conclusion, basal NO3– concentrations are substantially higher in human skeletal muscle tissue compared with plasma. Ingestion of a bolus of dietary NO3– increases both plasma and muscle NO3– contents in humans. NEW & NOTEWORTHY Literature of the pharmacokinetics following dietary nitrate ingestion is usually limited to the changes observed in plasma nitrate and nitrite concentrations. The present investigation assessed the skeletal muscle nitrate content in humans during the postabsorptive state, as well as following dietary nitrate ingestion. We show that basal nitrate content is higher in skeletal muscle tissue than in plasma and that ingestion of a dietary nitrate bolus strongly increases both plasma and muscle nitrate concentrations.
Source: Journal of Applied Physiology - Category: Physiology Authors: Tags: RESEARCH ARTICLE Source Type: research