Total Synthesis of ( −)-Nahuoic Acid Ci (Bii)

Total Synthesis of ( −)-Nahuoic Acid Ci (Bii): A convergent total synthesis of ( −)-nahuoic acid Ci(Bii) (3), a novelcis-decalin polyketide, has been achieved. Key synthetic transformations include Type II Anion Relay Chemistry (ARC) to construct the polyol chain, a Ti-catalyzed asymmetric Diels –Alder reaction to generate thecis-decalin skeleton, and a late-stage large fragment union exploiting a Micalizio alkoxide-directed alkyne –alkene coupling tactic.

Source: Organometallic Current - September 25, 2017 Category: Chemistry Tags: Total synthesis Source Type: blogs