Catalytic C(sp3) –H Alkylation via an Iron Carbene Intermediate

JacsCatalytic C(sp3) –H Alkylation via an Iron Carbene Intermediate: The catalytic transformation of a C(sp3) –H bond to a C(sp3) –C bond via an iron carbene intermediate represents a long-standing challenge. Despite the success of enzymatic and small molecule iron catalysts mediating challenging C(sp3) –H oxidations and aminations via high-valent iron oxos and nitrenes, C(sp3) –H alkylations via isoelectronic iron carbene intermediates have thus far been unsuccessful. Iron carbenes have been inert, or shown to favor olefin cyclopropanation and heteroatom-hydrogen insertion. Herein we report an iron phthalocyanine-catalyzed alkylation of allylic and benzylic C(sp3) –H bonds.

Source: Organometallic Current - September 25, 2017 Category: Chemistry Tags: C-H alkylation Fe catalyzed Source Type: blogs