CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice

CISH gene has been associated with increased susceptibility to human tuberculosis. We found that cish −/− mice had higher M. tuberculosis load in spleens and lungs up to 2.5 weeks after infection but not later compared to controls. Cish mRNA levels were increased in lungs at early and late time points after M. tuberculosis infection. In relation, the titers of inos and tnf mRNA in lungs were red uced early after infection of cish−/− mice.The transfer of cish−/− and control T cells conferred rag1−/− mice similar protection to infection with M.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Tags: Immunological Aspects Source Type: research