AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages

Advanced glycation end products (AGEs) are non-enzymatically glycated protein, lipid, or nucleic acid by Maillard reaction,1 found in extracellular fluid including blood plasma and tissues. AGEs are often increased in aging, but mainly in poorly controlled diabetes mellitus and chronic kidney disease2 and independently relate to total and cardiovascular mortality.3 By interacting with the receptor for AGE (RAGE), AGEs induce oxidative stress and NF-KB-mediated transactivation of inflammatory genes and Rage, leading to vascular damage.

Source: Journal of Diabetes and Its Complications - September 22, 2017 Category: Endocrinology Authors: Rodrigo Tallada Iborra, Adriana Machado-Lima, Ligia Shimabukuro Okuda, Paula Ramos Pinto, Edna R. Nakandakare, Ubiratan Fabres Machado, Maria Lucia Correa-Giannella, Russell Pickford, Tom Woods, Margaret A. Brimble, Kerry-Anne Rye, Rui Lu, Shinji Yokoyama Source Type: research