Influence of the intestinal microbiome on anastomotic healing in the colon and rectum

Colonic and rectal anastomotic leak has long plagued the surgeons, without much improvement despite decades of advances in suture technique and technology. At the intersection of microbiotal changes in flux via a combination of environmental factors and the virulent pathology of the organisms colonizing the gastrointestinal tract, lies an underappreciated mechanism and thus possible solution for anastomotic failure. Through pre-operative preparation, intra-operative manipulation, and post-operative management, the flora is constantly changing.
Source: Seminars in Colon and Rectal Surgery - Category: Gastroenterology Authors: Source Type: research