The influence of intestinal microbiome on wound healing and infection

Wound healing problems and surgical site infections are commonly attributed to improper intraoperative technique and perioperative infection control methods. However, overwhelming evidence is emerging to suggest that the intestinal microbiome plays a profound and previously underappreciated role in infectious outcomes of surgery. Surgical stress and perioperative medical interventions alter the community structure and function of the intestinal microbiome. The resultant intestinal dysbiosis exerts overarching effects on the host immune and neuroendocrine systems.
Source: Seminars in Colon and Rectal Surgery - Category: Gastroenterology Authors: Source Type: research