A 5-HT1Areceptor promoter polymorphism influences fronto-limbic functional connectivity and depression severity in bipolar disorder

Fronto-limbic circuitry dysfunction has been proposed as a possible endophenotype for bipolar disorder (BD). A chronic reduced or altered prefrontal modulation of limbic activity, especially in the amygdala (Amy) (Radaelli et al., 2014b), may identify a neurobiological basis for the pathophysiology and maintenance of the disorder (Frey et al., 2013; Vai et al., 2014). Activity and functional connectivity (FC) in this circuitry are influenced by challenges with serotonin reuptake inhibitors (SSRIs) antidepressant medications (Grady et al., 2013; Norbury et al., 2007) and by polymorphisms of the serotonin (5-HT) transporter gene, in healthy subject and bipolar patients (Dannlowski et al., 2010; Shah et al., 2009; Volman et al., 2013).
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research