Polyglutamine spinocerebellar ataxias — from genes to potential treatments

Nature Reviews Neuroscience 18, 613 (2017). doi:10.1038/nrn.2017.92 Authors: Henry L. Paulson, Vikram G. Shakkottai, H. Brent Clark & Harry T. Orr The dominantly inherited spinocerebellar ataxias (SCAs) are a large and diverse group of neurodegenerative diseases. The most prevalent SCAs (SCA1, SCA2, SCA3, SCA6 and SCA7) are caused by expansion of a glutamine-encoding CAG repeat in the affected gene. These SCAs represent a substantial portion of
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Review Source Type: research