Lowering Interleukin-12 Activity Improves Myocardial and Vascular Function Compared With Tumor Necrosis Factor-a Antagonism or Cyclosporine in Psoriasis [Ventricular Structure and Function]

Conclusions— In psoriasis, IL-12/23 inhibition results in a greater improvement of coronary, arterial, and myocardial function than TNF-α inhibition or cyclosporine treatment. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT02144857.

http://circimaging.ahajournals.org/cgi/content/short/10/9/e006283?rss=1

Source: Circulation: Cardiovascular Imaging - September 12, 2017 Category: Radiology Authors: Ikonomidis, I., Papadavid, E., Makavos, G., Andreadou, I., Varoudi, M., Gravanis, K., Theodoropoulos, K., Pavlidis, G., Triantafyllidi, H., Moutsatsou, P., Panagiotou, C., Parissis, J., Iliodromitis, E., Lekakis, J., Rigopoulos, D. Tags: Inflammatory Heart Disease, Atherosclerosis, Vascular Disease Ventricular Structure and Function Source Type: research