Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder

Lithium is the most commonly prescribed medication for the treatment of bipolar disorder (BD), yet the mechanisms underlying its beneficial effects are still unclear. We aimed to compare the effects of lithium treatment in lymphoblastoid cell lines (LCLs) from BD patients and controls. LCLs were generated from sixty-two BD patients (based on DSM-IV) and seventeen healthy controls matched for age, sex, and ethnicity. Patients were recruited from outpatient clinics from February 2012 to October 2014.

Source: European Neuropsychopharmacology - September 19, 2017 Category: Psychiatry & Psychology Authors: Gabriel R. Fries, Gabriela D. Colpo, Nancy Monroy-Jaramillo, Junfei Zhao, Zhongming Zhao, Jodi G. Arnold, Charles L. Bowden, Consuelo Walss-Bass Source Type: research