Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo [Original Articles]

Conclusions: Hyperphosphorylation of this serine in cTnI C terminus impacts heart function by depressing diastolic function at baseline and limiting systolic reserve under physiological stresses. However, paradoxically, it preserves heart function after ischemia/reperfusion injury, potentially by decreasing proteolysis of cTnI.

http://circheartfailure.ahajournals.org/cgi/content/short/10/9/e003850?rss=1

Source: Circulation: Heart Failure - September 12, 2017 Category: Cardiology Authors: Li, Y., Zhu, G., Paolocci, N., Zhang, P., Takahashi, C., Okumus, N., Heravi, A., Keceli, G., Ramirez-Correa, G., Kass, D. A., Murphy, A. M. Tags: Basic Science Research, Hemodynamics, Myocardial Biology, Pathophysiology, Heart Failure Original Articles Source Type: research