Role of ALDH1a and CD44 in transitional and squamous cell carcinomas of urinary bladder

Conclusion: ALDH1a expression was associated with unfavorable features such as advanced stage in TCC cases and high grade in SCC cases. ALDH1a+ cells constitute a subpopulation of CD44+ cells and might represent more primitive CSCs. Target therapy against ALDH1a could be effective, especially in advanced tumors. Target therapy against CD44 could be helpful for bladder SCC or TCC with squamous differentiation.
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research