Fragile histidine triad protein expression in colorectal adenoma and carcinoma: an immunohistochemical and image analysis study

Conclusion: The reduction of FHIT expression occurs with rising grade of dysplasia and malignant colorectal tumors and its low expression is associated with poor prognostic factors such as lymph node metastasis, presence of distant metastasis, vascular and perineural invasion, high grade, and advanced stages. Furthermore, the CIA technique provides a more accurate assessment of the staining patterns and helps to evaluate intensity better than when depending on subjective light microscopy alone.
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research