Predictive role of leptin and cyclin D1 in papillary thyroid carcinoma: an immunohistochemical study

Conclusion: We conclude that the expressions of leptin and cyclin D1 in PTC are associated with neoplasm aggressiveness, including advanced stage and presence of lymph node metastasis. Absence of both leptin and cyclin D1 expressions in normal noncancerous follicular cells and multinodular goiter cases indicates their role in early carcinogenesis of PTC. Novel opportunities could emerge from the discovery of leptin crosstalk with other oncogenic pathways, inflammatory and angiogenic cytokines, and links to obesity-related cancers.
Source: Egyptian Journal of Pathology - Category: Pathology Tags: Original Articles Source Type: research