Human dorsal root ganglion in vivo morphometry and perfusion in Fabry painful neuropathy

Conclusions: Patients with Fabry disease have severely enlarged dorsal root ganglia with dysfunctional perfusion. This may be due to glycolipid accumulation in the dorsal root ganglia mediating direct neurotoxic effects and decreased neuronal blood supply. These alterations were less pronounced in peripheral nerve segments. Thus, the dorsal root ganglion might play a key pathophysiologic role in the development of neuropathy and pain in Fabry disease.

http://www.neurology.org/cgi/content/short/89/12/1274?rss=1

Source: Neurology - September 18, 2017 Category: Neurology Authors: Godel, T., Bäumer, P., Pham, M., Köhn, A., Muschol, N., Kronlage, M., Kollmer, J., Heiland, S., Bendszus, M., Mautner, V.-F. Tags: MRI, Metabolic disease (inherited), Peripheral neuropathy, Neuropathic pain ARTICLE Source Type: research