Effect of simvastatin on CSF Alzheimer disease biomarkers in cognitively normal adults

Conclusions:
Simvastatin-related reductions in CSF p-tau181 concentrations may be modulated by LDL cholesterol. The potential disease-modifying effects of simvastatin on CSF phospho-tau should be further investigated in persons with hypercholesterolemia.

Source: Neurology - September 18, 2017 Category: Neurology Authors: Li, G., Mayer, C. L., Morelli, D., Millard, S. P., Raskind, W. H., Petrie, E. C., Cherrier, M., Fagan, A. M., Raskind, M. A., Peskind, E. R. Tags: Clinical trials Randomized controlled (CONSORT agreement), Alzheimer's disease ARTICLE Source Type: research