A Metabolomic Approach Applied to a Liquid Chromatography Coupled to High ‐Resolution Tandem Mass Spectrometry Method (HPLC‐ESI‐HRMS/MS): Towards the Comprehensive Evaluation of the Chemical Composition of Cannabis Medicinal Extracts

ConclusionsNotwithstanding the use of a standardised starting plant material, great changes are caused by different extraction procedures. The metabolomics approach is a useful tool for the evaluation of the chemical composition of cannabis extracts. Copyright © 2017 John Wiley & Sons, Ltd. Untargeted metabolomics was successfully applied to unveil the main differences between cannabis based medicinal extracts obtained using two different solvents and four extraction time points for each solvent. A series of cannabinoids and other relevant small molecules, including alkaloids and amino acids, were identified among the most discriminating metabolites. Our results suggested that the main difference lies in the ratio of acid to decarboxylated cannabinoids, which dramatically influences the pharmacological activity of CMEs.
Source: Phytochemical Analysis - Category: Biochemistry Authors: Tags: Research Article Source Type: research