Urinary WT1 ‐positive cells as a non‐invasive biomarker of crescent formation

ConclusionsThe results of our study suggest urinary WT1‐positive cells can be used to detect patients with crescent formation using 5 cells/10‐mL cutoff value. WT1‐positive glomerular podocytes and parietal epithelial cells may be shed into urine in active glomerular disease. This study, investigating the relationship between WT1‐positive cells in urine and in the renal biopsy found no correlation; however, the results do suggest that, using a cutoff value of 5 cells/10 mL, WT1 positive urinary cells can be used to detect patients with crescent formation.
Source: Cytopathology - Category: Pathology Authors: Tags: ORIGINAL ARTICLE Source Type: research