Divergent Interaction Profiles of Gabapentin and Levetiracetam with Dipalmitoylphosphatidylcholine Lipids

Conclusions According to the corresponding findings depending on concentrations both drugs incorporate into phosphatidylcholines, perturbing the packing of lipids and affecting their thermotropic properties. Their binding affinity to acyl chains and hydrophilic parts of lipids was found to highly correlate with lipid-water partition and their solubility degree in water. Hence, the obtained results may offer evaluation of partition profile of the drugs into biological membranes depending on concentration.
Source: International Journal of Epilepsy - Category: Neurology Source Type: research