Controllability and observability analysis of basal ganglia model and feedback linearisation control

This study shows that the BG model is controllable and observable. The authors also propose the idea of stimulating the two BG areas simultaneously. A two-part controller is then designed: a feedback linearisation controller for subthalamic nucleus stimulation and a partial state feedback controller for globus pallidus internal stimulation. The controllers are designed to decrease three indicators: the hand tremor, the level of delivered stimulation signal in disease condition, and the ratio of the level of delivered stimulation signal in health condition to disease condition. Considering these three indicators, the simulation results show satisfactory performance.
Source: IET Systems Biology - Category: Biology Source Type: research