DOTA-Tetrazine Probes with Modified Linkers for Tumor Pretargeting

Pretargeted radioimmunoimaging and -therapy approaches building on the bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) reaction between strained trans-cyclooctenes (TCO) and electron-deficient tetrazines (Tz) have yielded impressive results in recent years and have proven a vital alternative to biological pretargeting systems. After improvement of the TCO-antibody conjugates, we here report on our evaluation of a new series of radiolabeled Tz-probes.

Source: Nuclear Medicine and Biology - September 13, 2017 Category: Nuclear Medicine Authors: Tilman L äppchen, Raffaella Rossin, Tiemen R. van Mourik, Guillaume Gruntz, Freek J.M. Hoeben, Ron M. Versteegen, Henk M. Janssen, Johan Lub, Marc S. Robillard Source Type: research