Genome wide conditional mouse knockout resources

Publication date: Available online 12 September 2017 Source:Drug Discovery Today: Disease Models Author(s): C. Kaloff, K. Anastassiadis, A. Ayadi, R. Baldock, J. Beig, M.-C. Birling, A. Bradley, S.D.M. Brown, A. Bürger, W. Bushell, F. Chiani, F.S. Collins, B. Doe, J.T. Eppig, R.H. Finnell, C. Fletcher, P. Flicek, M. Fray, R.H. Friedel, A. Gambadoro, H. Gates, J. Hansen, Y. Herault, G.G. Hicks, A. Hörlein, M. Hrabé de Angelis, V. Iyer, P.J. de Jong, G. Koscielny, R. Kühn, P. Liu, K.C.K Lloyd, R.G. Lopez, S. Marschall, S. Martínez, C. McKerlie, T. Meehan, H. von Melchner, M. Moore, S.A. Murray, A. Nagy, L.M.J. Nutter, G. Pavlovic, A. Pombero, H. Prosser, R. Ramirez-Solis, M. Ringwald, B. Rosen, N. Rosenthal, J. Rossant, P. Ruiz Noppinger, E. Ryder, W.C. Skarnes, J. Schick, F. Schnütgen, P. Schofield, C. Seisenberger, M. Selloum, D. Smedley, E.M. Simpson, A.F. Stewart, L. Teboul, G.P. Tocchini Valentini, D. Valenzuela, A.P. West, W. Wurst The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6000 mutant mouse strains have been generated by the IKMC in collaboration with the International Mous...
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research