[Correspondence] Obesity and the nervous system: more questions

In their excellent Review, Phillipe O'Brien and colleagues1 describe the neurological consequences of obesity. However, the authors did not mention migraine, which is a common, chronic, disabling neurological disorder.2 Epidemiological research shows a link between migraine and obesity that is further substantiated by putative pathophysiological mechanisms.3 A body of evidence supports a role for adipokines (such as leptin, adiponectin, interleukin 6, and TNF- α, among others), which are mediators of inflammatory processes, in the onset, persistence, and progression of migraines.

Source: Lancet Neurology - September 13, 2017 Category: Neurology Authors: Ane M ínguez-Olaondo, Pablo Irimia, Gema Frühbeck Tags: Correspondence Source Type: research