[Comment] Imaging neuroinflammation to monitor α-synucleinopathy

Neuroinflammation in neurodegenerative diseases generally refers to a chronic immune response in the CNS, in which innate immune cells such as microglia and astrocytes are responsible for robust inflammatory responses and neuronal death. However, each neurodegenerative disease also has a preclinical period, during which potentially harmful inflammatory events might already be happening. With the advent of disease-modifying drugs, early detection of abnormal signals from the brain milieu during the preclinical phase is important because diagnostic symptoms, once developed, are so relentless that few therapeutic countermeasures are left for clinicians to use.

Source: Lancet Neurology - July 3, 2017 Category: Neurology Authors: Yasuomi Ouchi Tags: Comment Source Type: research