Age-dependent effects of acute methylphenidate on amygdala reactivity in stimulant treatment-naive patients with Attention Deficit/Hyperactivity Disorder

In the present study, we investigate whether methylphenidate (MPH) affects emotional processing and whether this effect is modulated by age. We measured amygdala reactivity with functional Magnetic Resonance Imaging (fMRI) during processing of angry and fearful facial expressions in male stimulant treatment-naive patients with ADHD (N=35 boys; N=46 men) and 23 healthy control subjects (N=11 boys; N=12 men). In ADHD patients, we also measured amygdala reactivity 90minutes after an acute oral challenge with MPH (0.5mg/kg).

Source: Psychiatry Research: Neuroimaging - September 12, 2017 Category: Psychiatry Authors: Marco A. Bottelier, Anouk Schrantee, Bart Ferguson, Hyke G.H. Tamminga, Cheima Bouziane, J.J. Sandra Kooij, Michiel B. de Ruiter, Liesbeth Reneman Source Type: research