BMP signaling regulates the skeletal and connective tissue differentiation during caudal fin regeneration in sailfin molly (Poecilia latipinna)

In this study, we investigated the effects of BMP inhibition by LDN193189 on skeletal and connective tissues formation, at 5 days post amputation in the caudal fin of Poecilia latipinna. We observed that BMP inhibition leads to compromised growth of fin regenerate. Histological analysis supports the findings, as stunted progression of skeletal elements and below par formation of collagen. Biochemical analysis of collagen and subsequent transcript level analysis of genes that regulate the formation of skeletal elements reaffirm these observations. Overall, our results highlight the significance of BMP signaling in directing the blastemal cells for proper skeletal and connective tissue differentiation during caudal fin regeneration.
Source: Development, Growth and Differentiation - Category: Research Authors: Tags: Original Article Source Type: research