Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block

This study provides in vivo and in vitro transcriptome-support that injury may be mediated by an effect of Type I Interferon on fetal fibroblasts.

Source: AJP: Heart and Circulatory Physiology - September 12, 2017 Category: Cardiology Authors: Clancy, R. M., Markham, A. J., Jackson, T., Rasmussen, S. E., Blumenberg, M., Buyon, J. P. Tags: RESEARCH ARTICLE Source Type: research