The eukaryotic gut virome in hematopoietic stem cell transplantation: new clues in enteric graft-versus-host disease
Nature Medicine 23, 1080 (2017).
doi:10.1038/nm.4380
Authors: Jérôme Legoff, Matthieu Resche-Rigon, Jerome Bouquet, Marie Robin, Samia N Naccache, Séverine Mercier-Delarue, Scot Federman, Erik Samayoa, Clotilde Rousseau, Prescillia Piron, Nathalie Kapel, François Simon, Gérard Socié & Charles Y Chiu
Much attention has been focused on the role of the bacterial microbiome in human health, but the virome is understudied. Although previously investigated in individuals with inflammatory bowel diseases or solid-organ transplants, virome dynamics in allogeneic hematopoietic stem cell transplantation (HSCT) and enteric graft-versus-host disease (GVHD) remain unexplored. Here we characterize the longitudinal gut virome in 44 recipients of HSCT using metagenomics. A viral 'bloom' was identified, and significant increases were demonstrated in the overall proportion of vertebrate viral sequences following transplantation (P = 0.02). Increases in both the rates of detection (P
Source: Nature Medicine - Category: General Medicine Authors: J é r ô me Legoff Matthieu Resche-Rigon Jerome Bouquet Marie Robin Samia N Naccache S é verine Mercier-Delarue Scot Federman Erik Samayoa Clotilde Rousseau Prescillia Piron Nathalie Kapel Fran ç ois Simon G é rard Soci é Charles Y Chiu Tags: Letter Source Type: research
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