SPOP tips the balance of BETs in cancer

Nature Medicine 23, 1014 (2017). doi:10.1038/nm.4398 Authors: Katie A Fennell & Mark A Dawson Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.
Source: Nature Medicine - Category: General Medicine Authors: Tags: News and Views Source Type: research