Is LogP Truly Dead?

More than 100 years ago, the importance of lipophilicity to the passive permeability of molecules through the blood-brain-barrier was recognized. In the intervening decades, various methods to measure the lipid nature of molecules were developed; with an ever-expanding database on molecule structures and measured physiochemical properties, computational methods for estimation of lipophilicity followed. Today, the simple estimate of lipophilicity known as the logP value (in its original definition, the logarithm of the distribution ratio for a molecule between immiscible organic and aqueous layers) is routinely used in drug design, including radiopharmaceuticals.
Source: Nuclear Medicine and Biology - Category: Nuclear Medicine Authors: Source Type: research