Early recovery of circulating immature B cells in B ‐lymphoblastic leukemia patients after CD19 targeted CAR T cell therapy: A pitfall for minimal residual disease detection*+

Conclusions: These circulating CD10+B‐cells are compatible with immature B‐cells, and are a reflection of B‐cell recovery within the marrow. They are immunophenotypically distinguishable from residual B‐ALL. Expression of light chain sIg and key surface antigens characterizing regenerating B‐cell precursors can distinguish immature B‐cells from B‐ALL MRD and prevent misdiagnosis. This article is protected by copyright. All rights reserved.
Source: Cytometry Part B: Clinical Cytometry - Category: Molecular Biology Authors: Tags: Original Article Source Type: research