Low angiomotin ‐p130 with concomitant high Yes‐associated protein 1 expression is associated with adverse prognosis of advanced gastric cancer

In this study, a total of 166 patients with AGC were enrolled, and AMOT‐p130 and YAP1 levels were analyzed by immunohistochemistry using tissue microarrays. Low AMOT‐p130 together with high YAP1 expression (n = 30, 18.1%) was associated with high T stage (p = 0.042), high TNM stage (p = 0.025), and venous invasion (p = 0.048). A Kaplan–Meier survival analysis with log‐rank test revealed a significant correlation with decreased AMOT‐p130 coupled with high nuclear YAP1 expression with shorter overall survival (p = 0.0045) and disease‐free survival (p = 0.0028). Furthermore, multivariate analyses showed that the low AMOT‐p130/high YAP1 expression profile was an independent prognostic factor for disease‐free survival (p = 0.008, HR = 1.874, CI, 1.177–2.986) and overall survival (p = 0.012, HR = 1.903, CI, 1.152–3.143). Our findings collectively demonstrate that low AMOT‐p130 combined with high YAP1 expression is correlated with an unfavorable AGC prognosis.
Source: APMIS - Category: Research Authors: Tags: Original Article Source Type: research