Experimental and modelling characterisation of adjustable hollow Micro-needle delivery systems

Patch-based drug delivery offers certain appealing features, such as non-invasiveness and the ability to provide controlled release over time. However, it faces a significant challenge in increasing skin permeability, as most macromolecular drugs exhibit poor permeability owing to the existence of stratum corneum as a natural barrier [1,2]. Other approaches have been applied, such as chemical/lipid enhancers and physical means of assisting permeability to overcome the skin barrier. However, these methods are rarely used in clinical applications for various reasons, such as skin allergies, low effectiveness and inconvenience [1,2].
Source: Medical Engineering and Physics - Category: Biomedical Engineering Authors: Source Type: research