TGF ‐β1 attenuated branching morphogenesis of embryonic murine submandibular gland through Smad3 activation

Summary Transforming growth factor‐β1 (TGF‐β1) plays several crucial regulatory roles in multiple physiological and pathological processes. The aim of this work was to investigate the role of TGF‐β1 in branching morphogenesis of salivary gland. We harvested and cultured submandibular salivary glands (SMGs) from murine embryos, which were then treated with exogenous TGF‐β1, or its neutralized antibody, Smad3 inhibitor, or Smad3 small interfering RNA (siRNA). Our results suggested that TGF‐β1 attenuated branching morphogenesis of embryonic murine SMG via Smad3 activation, thus playing a negative regulatory role in salivary gland development.
Source: Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C - Category: Veterinary Research Authors: Tags: SHORT COMMUNICATION Source Type: research