HLA polymorphisms and risk of red blood cell alloimmunisation in polytransfused patients with sickle cell anaemia

ConclusionThis study suggests that polytransfused patients with SCA possessing the HLA‐DQB1*03 and HLA‐C*06 allele variants are more susceptible to alloimmunisation. In addition, HLA‐DRB1*04 and HLA‐DRB1*11 alleles were seen to be associated with the production of anti‐Fya and anti‐K antibodies, respectively.

Source: Transfusion Medicine - September 1, 2017 Category: Hematology Authors: C. Rodrigues, A. M. Sell, G. A. S. Guelsin, T. T. Higa, S. Pagliarini e Silva, L. C. Macedo, E. Â. Sippert, J. B. de Alencar, Â. Zanette, C. R. L. Acorsi, L. Castilho, J. E. L. Visentainer Tags: ORIGINAL ARTICLE Source Type: research