Ionophore A23187 shows anti-tuberculosis activity and synergy with tebipenem

The objective of this study was to find molecules with anti-mycobacterial activity from a natural compounds library, investigate their mechanisms of resistance, and assess their synergy with antibiotics. We screened a library of 2582 natural compounds with Mycobacterium aurum with the aim of identifying molecules with anti-mycobacterial activity. The hits with the lowest MICs in M. aurum were also tested for their antimicrobial activity in other mycobacterial species including M. tuberculosis complex strains.
Source: Tuberculosis - Category: Respiratory Medicine Authors: Tags: Drug Discovery and Resistance Source Type: research