Low adherence to antidepressants is associated with increased mortality following stroke: A large nationally representative cohort study

Post stroke depression is common and pervasive. In the general population, there has been some controversy that antidepressant (AD) medication is associated with premature mortality. Data is still lacking regarding the association between adherence to antidepressants (AD) and all-cause mortality. In this retrospective analysis of a population-based cohort of patients, 32,361 post-stroke patients who purchased at least one AD were followed for all-cause mortality over 4-years. Adherence to AD was measured as a ratio between dispensed and prescribed durations and was modeled as: non-adherence (80%, n=12,978) adherence.
Source: European Neuropsychopharmacology - Category: Psychiatry & Psychology Authors: Source Type: research