Prophylactic octreotide for pancreatoduodenectomy: more harm than good?

ConclusionThis multi‐institutional study, using ISGPF criteria, evaluates POPF development across the entire risk spectrum. Octreotide appears to confer no benefit in preventing a CR‐POPF, and may even potentiate CR‐POPF development in the presence of risk factors. This analysis suggests octreotide should not be utilized as a POPF mitigation strategy.

Source: HPB: official journal of the International Hepato Pancreat Biliary Association - July 1, 2014 Category: Gastroenterology Authors: Matthew T. McMillan, John D. Christein, Mark P. Callery, Stephen W. Behrman, Jeffrey A. Drebin, Tara S. Kent, Benjamin C. Miller, Russell S. Lewis, Charles M. Vollmer Tags: Original Article Source Type: research