Pyrimidinylacetamide-based 2-pyridylureas as Angiogenesis Inhibitors: Design, Synthesis and Biological Evaluation

VEGFR-2 inhibitors have been widely used in the treatment of cancer. In our continued efforts to search for potent and novel VEGFR-2 inhibitors as antitumor agents, we have identified a series of ureas and amides bearing a oxazolopyrimidine scaffold.

Source: Archives of Medical Research - September 4, 2017 Category: Research Authors: Ya-hui Deng, Zhong-hui Yan, Ji-ping Liu, Yu Liu, Li-ping Sun Tags: Original Article Source Type: research