Who Can Diagnose Parkinson's Disease First? Role of Pre-motor Symptoms

In 1817, James Parkinson described the disease which bears his name. The disease was defined as a neurological syndrome characterized by tremor, rigidity, and slowness of movements. Almost one hundred years later, degeneration of neurons in the substantia nigra and low levels of dopamine were identified as the putative cause of the disease, thus the disease remained as a pure neurological disorder. In the late 1990s, non-motor symptoms of the disease began to gain interest because of their clinical relevance, as well as for their potential role in broadening the understanding of the pathophysiological mechanisms involved.

Source: Archives of Medical Research - September 4, 2017 Category: Research Authors: Mayela Rodr íguez-Violante, Rosalía Zerón-Martínez, Amin Cervantes-Arriaga, Teresa Corona Tags: Review Article Source Type: research