Antenatal/early postnatal hypothyroidism alters arterial tone regulation in 2-week-old rats

In conclusion, thyroid hormones deficiency suppresses the anticontractile effect of NO and potentiates the procontractile Rho-kinase effects in mesenteric arteries of 2-week-old pups. Such alterations disturb perinatal cardiovascular homeostasis and might lead to cardiovascular pathologies in adulthood.

Source: Journal of Endocrinology - September 4, 2017 Category: Endocrinology Authors: Sofronova, S. I., Gaynullina, D. K., Shvetsova, A. A., Borzykh, A. A., Selivanova, E. K., Kostyunina, D. S., Sharova, A. P., Martyanov, A. A., Tarasova, O. S. Tags: Research Source Type: research