Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease

Nature Genetics 49, 1392 (2017).
doi:10.1038/ng.3914

Authors: Derek Klarin, Qiuyu Martin Zhu, Connor A Emdin, Mark Chaffin, Steven Horner, Brian J McMillan, Alison Leed, Michael E Weale, Chris C A Spencer, François Aguet, Ayellet V Segrè, Kristin G Ardlie, Amit V Khera, Virendar K Kaushik, Pradeep Natarajan & Sekar Kathiresan
UK Biobank is among the world's largest repositories for phenotypic and genotypic information in individuals of European ancestry. We performed a genome-wide association study in UK Biobank testing ∼9 million DNA sequence variants for association with coronary artery disease (4,831 cases and 115,455 controls) and carried out meta-analysis with previously published results. We identified 15 new loci, bringing the total number of loci associated with coronary artery disease to 95 at the time of analysis. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.

Source: Nature Genetics - July 17, 2017 Category: Genetics & Stem Cells Authors: Derek Klarin Qiuyu Martin Zhu Connor A Emdin Mark Chaffin Steven Horner Brian J McMillan Alison Leed Michael E Weale Chris C A Spencer Fran ç ois Aguet Ayellet V Segr è Kristin G Ardlie Amit V Khera Virendar K Kaushik Pradeep Natarajan Sekar Kathiresan Tags: Letter Source Type: research