The basic amino acids in the coiled-coil domain of CIN85 regulate its interaction with c-Cbl and phosphatidic acid during epidermal growth factor receptor (EGFR) endocytosis

Point mutation of basic amino acids in the coiled-coil domain of the adaptor protein CIN85 indicate the importance of these residues for the interaction of CIN85 with c-Cbl and phosphatidic acid.

Source: BMC Biochemistry - July 8, 2014 Category: Biochemistry Authors: Xiudan ZhengJing ZhangKan Liao Source Type: research